Genes are gained and lost over the course of evolution. A recent study found that over 1,800 new genes have appeared during primate evolution and that an unexpectedly high proportion of these genes are expressed in the human brain. But what are the molecular functions of newly evolved genes and what is their impact on an organism's fitness? The acquisition of new genes may provide a rich source of genetic diversity that fuels evolutionary innovation. Although gene manipulation experiments are not (...) feasible in humans, studies in model organisms, such as Drosophila melanogaster, have shown that new genes can quickly become integrated into genetic networks and become essential for survival or fertility. Future studies of new genes, especially chimeric genes, and their functions will help determine the role of genetic novelty in the adaptation and diversification of species. (shrink)

Trabajo intelectual y trabajo manual -- La historia de la filosofía en la enseñanza de la filosofía -- Sobre el estoicismo -- La concepción de tiempo en el libro XI de las Confesiones de San Agustín -- Sobre la muerte.

Physicalism is the default position in science and in the philosophy of mind, but it should not be, I argue, because of two errors. By its epistemological error, physicalism gives physics priority over the evidence of first person experience. Only what I experience in first person is certain, so observation is prior to any theory. Physics itself is based on observation, avoiding the epistemological error, and then physics can progress, even changing its own ontology. However, physicalism imposes the ontology of (...) physics on every science, and in physics everything is causal. By its ontological error, physicalism tries to explain causally what is intentional. And it happens that causality and intentionality are mutually exclusive, showing that the ontology of physics is insufficient wherever intentions are present. This ontological insufficiency prevents that physicalism can repeat the success of physics with any science where intentions play a rôle, and thus it is blocking the advance of both the social sciences and the philosophy of mind. To overcome this obstacle, I propose to go back to the essentials: we should consider again the transcendental problem raised by Descartes and its solutions by Hume and Kant. On top of this subjectivist solution, we should take advantage of Darwin and Turing, and we should extend our ontology beyond causality to include intentionality, and here my proposal is problem solving. Then you could join our Post-Kantian subjectivism and say with me: The world is not a huge machine, as physicalism proposes, but an enigmatic problem. (shrink)

Much of the human research conducted in the United States or by U.S. researchers is regulated by the Common Rule. The Common Rule reflects the decision of 17 federal agencies, including the Department of Health and Human Services, to require that investigators follow the same rules for conducting human research., though there is significant overlap with the Common Rule.) Many of the obligations delineated in the Common Rule can be traced back to the work of the National Commission for the (...) Protection of Human Subjects of Biomedical and Behavioral Research. The National Commission was appointed in 1974 as part of the National Research Act in response to revelations about serious abuses involving human subjects, most notably the Tuskegee/United States Public Health Service Syphilis Study. (shrink)

Name der Zeitschrift: Nietzsche-Studien Jahrgang: 43 Heft: 1 Seiten: 195-199.

After reviewing the historical fortune of Nietzsche as a political thinker, it is discussed what aspects of his philosophy can be most useful for the deployment of a pluralist democracy, in the sense of political agonism claimed today by some of his interpreters. But the reasons why an articulation of democracy and aristocratic culture is coagulated in his philosophy are also pointed out. For this, the question of the agon in Nietzsche is approached and its discrepancy with the Schmittian idea (...) of the friend-enemy pair, as distinctive of the essence of the political, is pointed out, thus placing the Nietzschean critique of modernity in perspective. (shrink)

An anonymous biography of Lucan known as the Life of Vacca attributes to the poet the composition of a work called Siluae. This information has been accepted by scholars with regard to both Lucan and Statius, thus transforming Lucan into a predecessor of Statius’ Siluae. This article seeks to demonstrate that neither the manuscript tradition of Lucan's biography nor alleged references to Lucan's Siluae in Statius’ collection substantiate the affirmation that Lucan composed a work called Siluae. It is argued that (...) the Life of Vacca is most probably late and its very long catalogue of works (mostly problematic or otherwise unknown) aggrandizes Lucan in response to the need for a commendatory biography of the poet when he became a school author. Pomponio Leto is responsible for perpetuating the mention of Lucan's Siluae by including it in his influential biography of Lucan (the first to reach the printed press). It is further argued that the circumstances of the tradition of Statius’ Siluae explain Leto's acceptance of Lucan's work of the same title. Leto was working on a commentary on the recently rediscovered Siluae, which explains his inclusion of a work called Siluae in his biography of Lucan, a great poet who had preceded Statius. Finally, this article deconstructs the theories that find references to Lucan's Siluae in Statius’ Siluae or that justify Statius’ silence about Lucan's Siluae with its political motifs. (shrink)

Estudio Bibliográfico de / A Bibliographical Study of: José M. Sevilla, Ragione narrativa e ragione storica. Una prospettiva vichiana su Ortega y Gasset. Introducción de Giuseppe Cacciatore. Guerra Edizioni, Perugia, 2002, pp. 269. I.S.B.N. 88-7715-615-5.

En noviembre de 1976, Amnesty Internacional llegó al país a constatar denuncias sobre violaciones a los derechos humanos. Dos de sus integrantes llegaron a la ciudad de Córdoba. El Hotel Crillón, ubicado en plena city cordobesa y locación donde se alojaron los visitantes, fue el escenario de las acciones de espionaje, persecución y amedrentamiento que sufrieron los dos delegados, un varón y una mujer, que habían llegado para contactarse con posibles denunciantes. Al no poder constituirse como un refugio seguro para (...) expresar aquello que las autoridades negaban, el artículo analiza cómo se frustró esta visita en base a los informes elevados por la Policía Federal a través de un memorando reservado. En la misma se contextualiza el momento, apoyándonos en la historia de la represión local, y se procura una lectura analítica del documento resguardado en el Archivo Provincial de la Memoria de Córdoba. Asimismo, se ofrece su cotejo y contraste con otras informaciones provenientes de testimonios vertidos en diferentes momentos. ¿Cómo y por qué se frustró la visita? ¿Quiénes tuvieron contacto con los visitantes y por qué no fue posible contactar a los familiares y allegados de la/os represaliada/os? ¿Qué testimonios posteriores se conocieron de este acontecimiento frustrado? ¿Cómo habrá incidido en la costosa configuración de la cuestión de los derechos humanos en Córdoba, algo que hemos demostrado en nuestras investigaciones previas del tema? Por fin, ¿qué nos dice este evento de las características de la represión local, de los modos de informar y de las actitudes sociales en dictadura? (shrink)

Nos ocupamos aquí de una cuestión de importancia para la filosofía moderna, y para la filosofía leibniziana en particular, como es el concepto de substancia. Veremos cómo, en Leibniz, la divisibilidad de la materia al infinito y la necesidad de un principio que dé razón de la unidad en la multiplicidad de los elementos que componen todo cuerpo, lo llevan a concebir unidades metafísicas que son su fundamento. Asimismo, la respuesta a esta cuestión alude al problema del cuerpo de una (...) manera que presenta una singular complejidad, y exige seguir cierto itinerario de conceptos, con especial cuidado a las variaciones que el propio Leibniz realiza en su concepción de la substancia a lo largo de la evolución de su filosofía. Finalmente, nos ocupamos de las nociones de unidad y composición, vinculadas al llamado pluralismo substancial leibniziano. (shrink)

Following Post program, we will propose a linguistic and empirical interpretation of Gödel’s incompleteness theorem and related ones on unsolvability by Church and Turing. All these theorems use the diagonal argument by Cantor in order to find limitations in finitary systems, as human language, which can make “infinite use of finite means”. The linguistic version of the incompleteness theorem says that every Turing complete language is Gödel incomplete. We conclude that the incompleteness and unsolvability theorems find limitations in our finitary (...) tool, which is our complete language. (shrink)

El cambio en la sociedad digital y compleja requiere de la elaboración de un marco filosófico empresarial adaptado al nuevo paradigma del siglo XXI. La empresa es una institución moderna de enorme influencia y poder y se revela como un agente de cambio, creador de realidades, impulsor de innovación y catalizador de la transformación y el desarrollo personal. Las nuevas culturas empresariales han de poner el foco de atención en la persona, como fuente de avance y progreso, siendo el Humanismo (...) la corriente que adquiere sentido y protagonismo para potenciar el papel del hombre y de la mujer en un contexto veloz, complejo, incierto, cambiante y turbulento. (shrink)

Vardanyan’s Theorems [36, 37] state that $\mathsf {QPL}(\mathsf {PA})$ —the quantified provability logic of Peano Arithmetic—is $\Pi ^0_2$ complete, and in particular that this already holds when the language is restricted to a single unary predicate. Moreover, Visser and de Jonge [38] generalized this result to conclude that it is impossible to computably axiomatize the quantified provability logic of a wide class of theories. However, the proof of this fact cannot be performed in a strictly positive signature. The system $\mathsf (...) {QRC_1}$ was previously introduced by the authors [1] as a candidate first-order provability logic. Here we generalize the previously available Kripke soundness and completeness proofs, obtaining constant domain completeness. Then we show that $\mathsf {QRC_1}$ is indeed complete with respect to arithmetical semantics. This is achieved via a Solovay-type construction applied to constant domain Kripke models. As corollaries, we see that $\mathsf {QRC_1}$ is the strictly positive fragment of $\mathsf {QGL}$ and a fragment of $\mathsf {QPL}(\mathsf {PA})$. (shrink)

Drawing from Goffman’s original observations on stigma and the consequences of interactions between the stigmatized and supportive or stigmatizing audiences, we conduct a 20-year review of the diverse literature on stigma to revisit the collective nature of stigmatization processes. We find that studies on stigma’s origins, responses, processes, and outcomes have diverged from Goffman’s relational view of stigma as they have overlooked important relational mechanisms explaining the processes of (de)stigmatization. We draw from those conclusions to justify the need to study (...) stigma as a collective phenomenon. We develop a relational perspective on stigma based on understanding how attributes are stigmatized (or not) by audiences in their interactions. We argue that to advance stigma research, it is necessary to build on Goffman’s theory to include the stigmatizers (i.e., the normal) and supporters (i.e., the wise); how they create, sustain, or remove stigma; and how they relate to the stigmatized (i.e., the targets). Accordingly, we provide a research agenda on stigma as a collective phenomenon that theorizes a relational perspective, proposes a typology of how audiences relate to stigmatization, and identifies patterns of relations between audiences. We thus offer a missing piece to existing accounts of stigma by focusing on the key role of audiences (i.e., stigmatizers or supporters of the stigmatized) rather than on the targets of stigma (i.e., the own). (shrink)

In 2020, the European Union announced the award of the contract for the biometric part of the new database for border control, the Entry Exit System, to two companies: IDEMIA and Sopra Steria. Both companies had been previously involved in the development of databases for border and migration management. While there has been a growing amount of publicly available documents that show what kind of technologies are being implemented, for how much money, and by whom, there has been limited engagement (...) with digital methods in this field. Moreover, critical border and security scholarship has largely focused on qualitative and ethnographic methods. Building on a data feminist approach, we propose a transdisciplinary methodology that goes beyond binaries of qualitative/quantitative and opacity/transparency, examines power asymmetries and makes the labour of coding visible. Empirically, we build and analyse a dataset of the contracts awarded by two European Union agencies key to its border management policies – the European Agency for Large-Scale Information Systems (eu-LISA) and the European Border and Coast Guard Agency (Frontex). We supplement the digital analysis and visualisation of networks of companies with close reading of tender documents. In so doing, we show how a transdisciplinary methodology can be a device for making datafication ‘intelligible’ at the European Union borders. (shrink)

Este artículo1 explora dos obras cinematográficas guatemaltecas, Polvo (2012) y Nuestras madres (2019), dirigidas por Julio Hernández Cordón y César Díaz correspondientemente. En ambos largometrajes la denuncia sobre la violación de derechos humanos durante el pasado conflicto armado guatemalteco, la búsqueda de padres o familiares desaparecidos y sus secuelas en las víctimas constituyen la temática central. Por tanto, el análisis se centra en la importancia que tiene la búsqueda del padre desaparecido en los hijos, quienes, a raíz de esta vivencia (...) traumática, experimentan un vacío identitario, así como estragos individuales provocados por la falta de la figura paterna. Por otro lado, también se analizan el trauma y el silencio de las madres sobrevivientes como remanente del miedo/terror experimentado durante el conflicto armado, pero también como un mecanismo de protección para sus hijos. En especial, el análisis se auxilia teóricamente con el extenso trabajo realizado por el sociólogo uruguayo Gabriel Gatti sobre la desaparición forzada. 1 Este ensayo forma parte de una serie de proyectos de investigación y se realizó con el apoyo de la beca Volgenau de la Academia Naval de Estados Unidos. (shrink)

Fencing for the blind and visually impaired is an emerging sub-discipline of fencing that creates unusual conditions for meaning-making through interaction between embodied endowments and worldly affordances. With the rules of fencing slightly adjusted to the needs of the blindfolded participants – regardless of their sightedness – the discipline requires the fencers to engage in a duel by relying on other than visual cues. This article explores what an autoethnographic account of experiences of participation in fencing for the blind and (...) visually impaired brings to debates on the embodied, and specifically sensory difference. The discussion of these experiences intersects with debates on affect, affordance, and habit, with all three having important roles in related semiotic processes. Presented vignettes draw upon the author’s lived experiences of participation in fencing for the blind and visually impaired and are analyzed as part of a mixed-method autoethnographic study, accompanied by sensory methodologies, with a focus on an inquiry beyond the visual. The vignettes elucidate how we make sense of our surroundings through a complex engagement with the ecology of sensory and affective processes. In addition to exploring the role of affective and pre-conceptual aspects of our experiences, the article seeks to understand how semiosis occurs through both exposure to as well as the active pursuit of specific environmental signs available to us. The article also derives from biosemiotics to examine the complex relationship between meaning-making processes and habits. Finally, the autoethnographic account provides an insight into how we habituate the world and our embodied differences and thus enable meaning-making processes. (shrink)

Cette étude vise à comprendre les spécificités sémantiques des lexèmes _manipuler_ et _modifier_ afin d’éclairer l’usage qui en est fait en bioéthique lorsque les actions désignées ont comme objet l’embryon, le cerveau, l’ADN, l’Homme, le vivant ou la procréation. En s’appuyant sur les définitions des dictionnaires et sur les réponses à un questionnaire soumis aux locuteurs, et en se servant de concepts de la sémantique combinatoire, de la sémantique argumentative, de la sémantique des cadres et de l’aspect sémantique, l’étude identifie (...) les éléments de signification propres à chacun des deux lexèmes. Ces éléments sont étroitement liés au potentiel de signification des lexèmes et aux traits aspectuels des procès qu’ils désignent. À l’issue de cette étude, un ensemble de traits sémantiques caractéristiques de chaque lexème est proposé, dans une perspective contrastive. (shrink)

This paper investigates the interpretation of counterfactual conditionals. The main goal of the paper is to provide an account of the semantic role of similarity in the evaluation of counterfactuals. The paper proposes an analysis according to which counterfactuals are treated as predications “ de re ” over past situations in the actual world. The relevant situations enter semantic composition via the interpretation of tense. Counterfactuals are treated as law-like conditionals with de re predication over particular facts. Similarity with respect (...) to particular facts is ensured by the semantics of tense in interaction with the modal, while the modal itself is responsible for invoking laws. In the paper, various arguments are provided to support a local view of similarity over the global approach found in semantics along the line of Lewis’s and Stalnaker’s. Arguments are also provided tying the evaluation of similarity to the interpretation of tense. Finally, arguments are provided to show that in key cases, the approaches make comparable predictions. (shrink)

Mary Livermore'sMy Story of the Waris a valuable piece of travel writing written from the point of view of a nurse who documented her unexpected personal and professional journey to administer the Sanitary Commission of the United States Union Army and provide nursing care during the American Civil War. Although Livermore's pre‐war background had not been solely limited to the domestic sphere, her wartime experience involved a public negotiation between the traditional domestic realm assigned to women and new nursing professional (...) functions that emerged during the war. In a context in which the general access of women to public writing was rather limited and in which nursing was not a formally regulated professional activity, Livermore's triumphal narrative reflects the increasing connection between progressively professional nursing functions that emerged in the context of war and a new women's rights leadership forged during her autobiographical journey. (shrink)

Este artículo1 explora dos obras cinematográficas guatemaltecas, Polvo (2012) y Nuestras madres (2019), dirigidas por Julio Hernández Cordón y César Díaz correspondientemente. En ambos largometrajes la denuncia sobre la violación de derechos humanos durante el pasado conflicto armado guatemalteco, la búsqueda de padres o familiares desaparecidos y sus secuelas en las víctimas constituyen la temática central. Por tanto, el análisis se centra en la importancia que tiene la búsqueda del padre desaparecido en los hijos, quienes, a raíz de esta vivencia (...) traumática, experimentan un vacío identitario, así como estragos individuales provocados por la falta de la figura paterna. Por otro lado, también se analizan el trauma y el silencio de las madres sobrevivientes como remanente del miedo/terror experimentado durante el conflicto armado, pero también como un mecanismo de protección para sus hijos. En especial, el análisis se auxilia teóricamente con el extenso trabajo realizado por el sociólogo uruguayo Gabriel Gatti sobre la desaparición forzada. 1 Este ensayo forma parte de una serie de proyectos de investigación y se realizó con el apoyo de la beca Volgenau de la Academia Naval de Estados Unidos. (shrink)

Margaret Archer plays a leading role in the sociological analysis of the relation between structure and agency, and particularly in the study of reflexivity. The main aim of this article is to discuss her approach, focusing on the main contributions and limitations of Archer’s theory of reflexivity. It is argued that even though her research is a pioneering one, proposing an operationalization of the concept of reflexivity in view of its empirical implementation, it also minimizes crucial social factors and the (...) dimensions necessary for a more complex and multi-dimensional study of the concept, such as social origins, family socialization, processes of internalization of exteriority, the role of other structure–agency mediation mechanisms and the persistence of social reproduction. (shrink)